Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals from your microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have identified recurrent mutations in genes regulating tumor cell-microenvironment interactions, w... https://winstoni297ahp4.ourcodeblog.com/profile