TAK-243 preferentially sure to UBA1 above the related E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lessened amounts of ubiquitylated proteins, improved markers of proteotoxic tension and DNA destruction pressure. In vivo, TAK-243 reduced leukemic load and qualified leukemic stem cells without having https://edwinp530fko3.wikiitemization.com/user