Phenobarbital lowers the plasma amounts of dicumarol (name previously used: bishydroxycoumarin) and will cause a minimize in anticoagulant action as calculated with the prothrombin time. Barbiturates can induce hepatic microsomal enzymes leading to enhanced metabolism and diminished anticoagulant response of oral anticoagulants (e. This is often also the motivation at https://lillianr988iuf2.angelinsblog.com/profile